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Background: Psychosocial factor is considered as intermediate social determinant of health, because it has powerful effects on health especially in women. Hence deeper understanding of the mental-health process needed for its promotion. The aim of this study was to explore women′s experience of the mental-health problem and related action-interactions activities to design the appropriate interventions. Methods: In-depth interviews with women 18-65 years were analyzed according to the grounded theory method. The selection of Participants was based on purposeful and theoretical sampling. Results: In this study, a substantive theory was generated; explaining how female with the mental-health problem handled their main concern, which was identified as their effort to achieve comfort (core variable). The other six categories are elements in this process. Daily stress as a trigger, satisfaction is the end point, marriage is the key point and action - interaction activities in this process are strengthening human essence, Developing life skills and help seeking. Conclusions: Better understanding the mental-health process might be useful to design the interventional program among women with mental-health problems.