Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma
oleh: Erik Jung, Matthias Osswald, Miriam Ratliff, Helin Dogan, Ruifan Xie, Sophie Weil, Dirk C. Hoffmann, Felix T. Kurz, Tobias Kessler, Sabine Heiland, Andreas von Deimling, Felix Sahm, Wolfgang Wick, Frank Winkler
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-02-01 |
Deskripsi
Whether the perivascular niche (PVN) and the integration into multicellular networks by tumor microtubes (TMs) have a different role in glioblastoma progression and resistance to therapies is currently unclear. Here, the authors, by long-term tracking of individual glioma, demonstrate that both niches can partially compensate for each other and that glioma cells localized in both niches are resistant to radio- and chemotherapy.