Generation of iPSC line (GIBHi001-A) from a patient with autism spectrum disorder
oleh: Shuai Li, Huifang Zhao, Rongqi Huang, Lang He, Chao Tian, Hualin Huang, Xiaobo Han, Feng Tang, Zuoxian Lin, Sihao Deng, Jianda Zhou, Zhiyuan Li
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2019-10-01 |
Deskripsi
Autism spectrum disorder (ASD) is a neurological disorder with complex etiologies. In this study, urine cells were collected from a 16-year-old male with ASD and reprogrammed with the human SKOM transcription factors. The patient has a heterozygous C > T mutation of FCGR1B gene that was confirmed by sequencing analysis. The pluripotency was verified by gene expression and capacity of differentiation towards the three germ layers. This kind of iPSC will be valuable for further understanding the pathogenesis of ASD and help to develop drugs for treating ASD.