SUMO-mediated regulation of NLRP3 modulates inflammasome activity
oleh: Rachael Barry, Sidonie Wicky John, Gianmaria Liccardi, Tencho Tenev, Isabel Jaco, Chih-Hong Chen, Justin Choi, Paulina Kasperkiewicz, Teresa Fernandes-Alnemri, Emad Alnemri, Marcin Drag, Yuan Chen, Pascal Meier
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-08-01 |
Deskripsi
The NLRP3 inflammasome is an important component of inflammatory responses, but how it is negatively regulated is still unclear. Here the authors show that post-translational modification of NLRP3 by sumoylation suppresses inflammasome activity, and that desumoylation of NLRP3 by the SENP6 and SENP7 proteases promotes NLRP3 activation.