Platelet Activation Pathways Controlling Reversible Integrin αIIbβ3 Activation
oleh: Jinmi Zou, Siyu Sun, Ilaria De Simone, Hugo ten Cate, Philip G. de Groot, Bas de Laat, Mark Roest, Johan W.M. Heemskerk, Frauke Swieringa
| Format: | Article |
|---|---|
| Diterbitkan: | Georg Thieme Verlag KG 2024-04-01 |
Deskripsi
Background Agonist-induced platelet activation, with the integrin αIIbβ3 conformational change, is required for fibrinogen binding. This is considered reversible under specific conditions, allowing a second phase of platelet aggregation. The signaling pathways that differentiate between a permanent or transient activation state of platelets are poorly elucidated.