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Background: High level of stress, anxiety and depression is seen among medical students. Aims: To assess the impact of brief structured yoga intervention on mental well being of MBBS students. Materials and Methods: The participants consisted of 82 MBBS students of 3 rd semester in the age group of 18-23 years. The students were assessed at baseline and at the end of one month of specific yoga intervention by using General Health Questionnaire-28 (GHQ-28). Results: The students reported improvement in general and mental well being following the intervention and difference was found to be highly significant. Conclusion: A short term specific yoga intervention may be effective in improving general and mental well being in MBBS students. It is feasible and practical to include yoga practice in block postings of community medicine.