Evaluation of Hydrogels Based on Oxidized Hyaluronic Acid for Bioprinting

oleh: Matthias Weis, Junwen Shan, Matthias Kuhlmann, Tomasz Jungst, Jörg Tessmar, Jürgen Groll

Format: Article
Diterbitkan: MDPI AG 2018-10-01

Deskripsi

In this study, we evaluate hydrogels based on oxidized hyaluronic acid, cross-linked with adipic acid dihydrazide, for their suitability as bioinks for 3D bioprinting. Aldehyde containing hyaluronic acid (AHA) is synthesized and cross-linked via Schiff Base chemistry with bifunctional adipic acid dihydrazide (ADH) to form a mechanically stable hydrogel with good printability. Mechanical and rheological properties of the printed and casted hydrogels are tunable depending on the concentrations of AHA and ADH cross-linkers.