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Evaluation of Hydrogels Based on Oxidized Hyaluronic Acid for Bioprinting
oleh: Matthias Weis, Junwen Shan, Matthias Kuhlmann, Tomasz Jungst, Jörg Tessmar, Jürgen Groll
Format: | Article |
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Diterbitkan: | MDPI AG 2018-10-01 |
Deskripsi
In this study, we evaluate hydrogels based on oxidized hyaluronic acid, cross-linked with adipic acid dihydrazide, for their suitability as bioinks for 3D bioprinting. Aldehyde containing hyaluronic acid (AHA) is synthesized and cross-linked via Schiff Base chemistry with bifunctional adipic acid dihydrazide (ADH) to form a mechanically stable hydrogel with good printability. Mechanical and rheological properties of the printed and casted hydrogels are tunable depending on the concentrations of AHA and ADH cross-linkers.