Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity
oleh: Aimee M. Deaton, Aditi Dubey, Lucas D. Ward, Peter Dornbos, Jason Flannick, AMP-T2D-GENES Consortium, Elaine Yee, Simina Ticau, Leila Noetzli, Margaret M. Parker, Rachel A. Hoffing, Carissa Willis, Mollie E. Plekan, Aaron M. Holleman, Gregory Hinkle, Kevin Fitzgerald, Akshay K. Vaishnaw, Paul Nioi
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-07-01 |
Deskripsi
Abdominal fat has been shown to increase cardiometabolic disease risk. In this study, the authors report that loss-of-function variants in the gene INHBE associate with lower BMI-adjusted waist-to-hip ratio, a surrogate measure of abdominal fat.