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Multiple myeloma (MM) is a plasma cell neoplasia and accounts 10% of the hemopoietic malignancies with mean age of 55 years and 5% of these disorders have extramedullary (EM) disease named as plasmacytomas (Pm). Pm is a solitary tumor of plasma cells and may be primary as solitary masses without bone marrow (BM) involvement or may accompany MM 1–4. Upper respiratory tract is most common site for EM involvement (80–90%). All the body sites including gastrointestinal tract (about 10%), genitourinary tract, reticuloendothelial system, thyroid, lungs, skin, and testicles can also be involved 4,5. First case with pancreatic Pm has been reported by Hefferman in 1947.6 Here pancreatic Pm has been reviewed; clinical, diagnostic prognostic and therapeutic approaches have been discussed. Keywords: Plasmacytoma, Pancreas, Multiple myeloma, Clinical findings, Treatment