Synthesis and In-vitro Antitumor Activity of 1-[3-(Indol-1-yl)prop-1-yn-1-yl]phthalazines and Related Compounds
oleh: Angelika Plenk, Johann Käferböck, Tamara Kabicher, Norbert Haider
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2007-08-01 |
Deskripsi
A series of novel 3-(indol-1-yl)prop-1-yn-1-yl-substituted phthalazines and related azines was prepared via a concise pathway by palladium-catalyzed cross-coupling of appropriate halo-azines and N-propargylindoles. Some of the compounds exhibited significant antitumor activity in an in-vitro assay.