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AIM:To evaluate the efficacy of pranoprofen combined with sodium hyaluronate in treatment of dry eye in recent years by Meta-analysis.<p>METHODS: According to the Cochrane systematic review method, the computer searched Medline, EMbase, Cochrane Library, Wanfang database, Weipu database, China Knowledge Network database, and included in the randomized controlled study of pranoprofen combined with sodium hyaluronate in the treatment of dry eye in 2014-2018, RevMan5.3 statistical software for data extraction and Meta-analysis.<p>RESULTS: A total of 8 randomized controlled trials, all in Chinese, totally 1 008 patients. Meta-analysis showed that compared with the use of sodium hyaluronate alone, prano fraction combined with sodium hyaluronate significantly improved the BUT, SⅠt, FL, dry eye symptoms and overall efficacy of the patients, the difference was statistically significant.<p>CONCLUSION: The efficacy of pranoprofen combined with sodium hyaluronate in treatment of dry eye was better than that of sodium hyaluronate alone.