Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression
oleh: Alyssa La Belle Flynn, Benjamin C. Calhoun, Arishya Sharma, Jenny C. Chang, Alexandru Almasan, William P. Schiemann
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-08-01 |
Deskripsi
Cancer cells can use autophagy as a mechanism of surviving from external stresses. Here, the authors show that Pfkfb3, a glycolytic gene, is expressed in metastatic breast cancer cells but not in dormant cells that demonstrate features of autophagy.