Iron-Catalysed Aerobic Oxidative C–C Bond Cleavage of Ketones for the Synthesis of Primary Amides

oleh: Haosheng Zhan, Zhiwei Hu, Weihua Tao, Min Ling, Wei Cao, Jing Lin, Zhenhua Liu, Yu Wang, Zhongxue Fang

Format: Article
Diterbitkan: Georg Thieme Verlag KG 2019-01-01

Deskripsi

Abstract An iron-catalysed aerobic oxidative C–C bond cleavage of ketones for the synthesis of primary amides has been developed using TEMPO and oxygen as an oxidant. This reaction tolerates a wide range of substrates, and primary amides are obtained in good to excellent yields. Substrates with long-chain alkyl substituents could also be selectively cleaved and converted into the corresponding amides.