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Siravedha/bloodletting is a worldwide favoured medical practice having its origin from the prehistoric era. Among many of its accomplished functions, Sushruta (the father of surgery) has also prescribed it in some Vatavyadhi (i.e., diseases predominantly causing pain/Shula due to Vata predominance). Vagbhat advised Raktamokshana/bloodletting as a treatment modality that relieves pain & redness immediately (Sadya Raga Ruja Samana). Throwing some light on the anatomical & physiological considerations lying behind the effectiveness of therapeutic bloodletting in neuromuscular conditions (Vatavyadhi) is of immense value for sustainment of para-surgical procedures in modern day medical practices.