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Tumors of the posterior fossa of brain leads to complications like brain stem compression, herniation and death because of its criti-cal location, limited space and involvement of vital brain stem nuclei. This study has been conducted in the department of Pathology and Neurosurgery, Gandhi Medical College, Secunderabad from December 2008 to December 2010. The aim and objectives of this study were to analyze the histological types and to determine the frequency of posterior cranial fossa tumors in children and adults at Gandhi Hospital, Hyderabad and to study the different clinical presentations of posterior fossa space occupying lesion (SOL) and its correlation with radiological and pathological findings. Each tumor type has a different mode of presentation according to the site. With advent of modern diagnostic modalities early diagnosis and treatment is possible.