PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells
oleh: Monika Raab, Mourad Sanhaji, Yves Matthess, Albrecht Hörlin, Ioana Lorenz, Christina Dötsch, Nils Habbe, Oliver Waidmann, Elisabeth Kurunci-Csacsko, Ron Firestein, Sven Becker, Klaus Strebhardt
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-03-01 |
Deskripsi
The overexpression of Polo-like kinase 1 (Plk1) promotes various cancers in humans; sporadic evidence suggests Plk1 could act as a tumor suppressor but the molecular basis for this effect are unclear. Here the authors show that Plk1 inhibition augments the tumorigenic capacity of a dominant-negative ∆APC mutant by increasing polyploidy and cell division.