NUAK2 is a critical YAP target in liver cancer
oleh: Wei-Chien Yuan, Brian Pepe-Mooney, Giorgio G. Galli, Michael T. Dill, Hai-Tsang Huang, Mingfeng Hao, Yumeng Wang, Han Liang, Raffaele A. Calogero, Fernando D. Camargo
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-11-01 |
Deskripsi
Hippo-YAP pathway plays an important role in cancers; however the in vivo relevance of YAP/TAZ target genes is unclear. Here, the authors show that NUAK2 is a target of YAP and participates in a feedback loop to maximize YAP activity. Inhibition of NUAK2 suppresses YAP-driven hepatomegaly and liver cancer growth, offering a new target for cancer therapy.