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Evaluation of Porous (Poly(lactide-<i>co</i>-glycolide)-<i>co</i>-(ε-caprolactone)) Polyurethane for Use in Orthopedic Scaffolds
oleh: Gaëlle Savin, Océane Sastourne-Array, Sylvain Caillol, Audrey Bethry, Michel Assor, Ghislain David, Benjamin Nottelet
Format: | Article |
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Diterbitkan: | MDPI AG 2024-02-01 |
Deskripsi
To develop an orthopedic scaffold that could overcome the limitations of implants used in clinics, we designed poly(ester-urethane) foams and compared their properties with those of a commercial gold standard. A degradable poly(ester-urethane) was synthetized by polyaddition between a diisocyanate poly(ε-caprolactone) prepolymer (PCL di-NCO, <i>M<sub>n</sub></i> = 2400 g·mol<sup>−1</sup>) and poly(lactic-<i>co</i>-glycolic acid) diol (PLGA, <i>M<sub>n</sub></i> = 2200 g·mol<sup>−1</sup>) acting as a chain extender. The resulting high-molecular-weight poly(ester-urethane) (PEU, <i>M<sub>n</sub></i> = 87,000 g·mol<sup>−1</sup>) was obtained and thoroughly characterized by NMR, FTIR and SEC-MALS. The porous scaffolds were then processed using the solvent casting (SC)/particle leaching (PL) method with different NaCl crystal concentrations. The morphology, pore size and porosity of the foams were evaluated using SEM, showing interconnected pores with a uniform size of around 150 µm. The mechanical properties of the scaffolds are close to those of the human meniscus (Ey = 0.5~1 MPa). Their degradation under accelerated conditions confirms that incorporating PLGA into the scaffolds greatly accelerates their degradation rate compared to the gold-standard implant. Finally, a cytotoxicity study confirmed the absence of the cytotoxicity of the PEU, with a 90% viability of the L929 cells. These results suggest that degradable porous PLGA/PCL poly(ester-urethane) has potential in the development of meniscal implants.