Clinically relevant GABARAP deficiency abrogates bortezomib-induced immunogenic cell death in multiple myeloma
oleh: Liwei Zhao, Zhe Shen, Guido Kroemer, Oliver Kepp
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2024-12-01 |
Deskripsi
ABSTRACTRecently, it was revealed that the high-risk, poor-prognosis downregulation of GABA type A receptor-associated protein (GABARAP) causes a defect in both autophagy and surface exposure of calreticulin (CALR) in multiple myeloma (MM) cells responding to bortezomib. Hence, GABARAP-defective MM cells fail to undergo immunogenic cell death.