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A field experiment was conducted during rainy season of 2009 at the research farm of the Indian Agricultural Research Institute, New Delhi to evaluate the appropriate combination of pre-emergence and post-emergence herbicides in direct-seeded rice (Oryza sativa L.). All the weed control treatments brought significant increase in grain (25-52%) and straw yield (27-58%) as compared to season long crop weed competition. Cyhalofop-butyl residues in soil were found below detectable level indicating safety to soil microbial population and succeeding crop. It may be concluded that weeds can be managed during critical period of competition with the sequential application of pretilachlor (750 g/ha) as pre-emergence followed by post- emergence application of cyhalofop-butyl (60 g/ha) at 30 DAS in direct-seeded rice.