Intestinal microbiome adjusts the innate immune setpoint during colonization through negative regulation of MyD88
oleh: Bjørn E. V. Koch, Shuxin Yang, Gerda Lamers, Jens Stougaard, Herman P. Spaink
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-10-01 |
Deskripsi
It remains unclear how microbial sensing during early-life colonization results in immune homeostasis rather than acute inflammation. Here the authors show that zebrafish larvae colonization suppresses intestinal MyD88, accounting for a considerable proportion of microbiota-induced alterations in immune setpoint.