Comprehensive and Computable Molecular Diagnostic Panel (C2Dx) From Small Volume Specimens for Precision Oncology: Molecular Subtyping of Non-Small Cell Lung Cancer From Fine Needle Aspirates
oleh: Jing Su, Jing Su, Jing Su, Lynn S. Huang, Ryan Barnard, Graham Parks, James Cappellari, Christina Bellinger, Travis Dotson, Lou Craddock, Bharat Prakash, Jonathan Hovda, Hollins Clark, William Jeffrey Petty, Boris Pasche, Michael D. Chan, Lance D. Miller, Jimmy Ruiz, Jimmy Ruiz
| Format: | Article |
|---|---|
| Diterbitkan: | Frontiers Media S.A. 2021-04-01 |
Deskripsi
The Comprehensive, Computable NanoString Diagnostic gene panel (C2Dx) is a promising solution to address the need for a molecular pathological research and diagnostic tool for precision oncology utilizing small volume tumor specimens. We translate subtyping-related gene expression patterns of Non-Small Cell Lung Cancer (NSCLC) derived from public transcriptomic data which establish a highly robust and accurate subtyping system. The C2Dx demonstrates supreme performance on the NanoString platform using microgram-level FNA samples and has excellent portability to frozen tissues and RNA-Seq transcriptomic data. This workflow shows great potential for research and the clinical practice of cancer molecular diagnosis.