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Stent thrombosis after percutaneous coronary intervention (PCI) is a challenging and life threatening situation. Thrombus aspiration, balloon angioplasty, use of newer antiplatelets and adjunctive glycoprotein IIb/IIIa inhibitors are commonly used as treatment modalities. Here we report a series of patients diagnosed with stent thrombosis treated with intracoronary thrombolytic therapy (Tenecteplase) with balloon dilatation. All had excellent outcome with TIMI 3 flow. Thus intracoronary thrombolysis would be a valuable option in stent thrombosis particularly with huge thrombus burden and thus avoiding the use of a second sent.