Longitudinal single-cell analysis of a myeloma mouse model identifies subclonal molecular programs associated with progression
oleh: Danielle C. Croucher, Laura M. Richards, Serges P. Tsofack, Daniel Waller, Zhihua Li, Ellen Nong Wei, Xian Fang Huang, Marta Chesi, P. Leif Bergsagel, Michael Sebag, Trevor J. Pugh, Suzanne Trudel
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-11-01 |
Deskripsi
The molecular programs that underlie progression in multiple myeloma (MM) are incompletely understood. Here the authors use a mouse model of MM and single-cell RNA-seq to define subclonal expression programs that arise during progression and that inform targeted therapeutic strategies.