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Septic arthritis is a rare health issue during neonatal period. It should be remembered that the treatment of this disease can lead to serious problems in the long term when it is late. In this series of cases, we presented arthrotomy and washing procedures in three neonatal patients with septic arthritis. We evaluated the pros and cons of the procedure and we compared it to non-surgical treatment methods. We have concluded that the washing procedure can be more effective than non-surgical methods.