Imaging characterization of an adult H3 K27M-altered diffuse midline glioma of the medulla oblongata with a confounding steroid response
oleh: Claudia Godi, MD, Paolo Garofalo, MD, Marcella Callea, MD, Paolo Vezzulli, MD, Maurizio Barbera, MD, Carlo Mandelli, MD, Elena Mazza, MD, Bianca Pollo, MD, Maria Rosa Terreni, MD, Antonella Castellano, MD PhD, Nicoletta Anzalone, MD, Andrea Falini, MD PhD
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2023-03-01 |
Deskripsi
We report an uncommon, infratentorial localization of adult H3 K27M-altered diffuse midline glioma arising in a particularly rare site (medulla oblongata). In addition to this unusual presentation, the lesion exhibited a substantial contrast enhancement and size decrease after dexamethasone, generating diagnostic dilemmas. Histology, molecular details, advanced Magnetic Resonance imaging features and differential diagnoses are here described and discussed, as well as common misconceptions about steroid-sensitive mass lesions, and practical difficulties for clinicians involved in the process of making diagnosis.