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Influence of adding CuO nanoparticles in the base fluid on flow and heat transfer in an inclined half-annulus was studied considering constant heat flux as boundary condition of hot wall. Control Volume based Finite Element Method (CVFEM) is applied in order to simulate procedure. Pressure gradient source terms are eliminated by using vorticity stream function formulation. Influences of CuO volume fraction, inclination angle and Rayleigh number on hydrothermal manners are presented. Results indicate that inclination angle makes changes in flow style. The strength of eddies reaches to its minimum value when the upper wall is hot. Temperature gradient enhances with rise of buoyancy forces while it reduces with augment of inclination angle. Keywords: Half-annulus enclosure, Nanofluid, Natural convection, CVFEM, Inclined enclosure