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A research was conducted among 686 patients of HIV/AIDS, who are proved with positive ELISA test and Western BLOT test. Out of these 686 patients 83.1%, were suffering from full blown AIDS, 16.9% were HIV seropositive. Number of males and females affected with seroposdive and AIDS with different age groups were recorded. Detailed clinical examination of oral cavity was carried out for all the patients to find out the various classical oral manifestations of HIV/AIDS and the observations were recorded. A total number of 15 different oral mucosal lesions were recorded among Indian population in the research. The study has proved that oral manifestations of AIDS occurred in 86% HIV/AIDS patients. Research findings were recorded with classical oral mucosal lesions of HIV/AIDS. This is a clinical research on HIV/AIDS patients.