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Graves’ disease (GD), an organ-specific autoimmune disease, is t he most common cause of hyperthyroidism. Tumour necrosis factor-alpha (TNF-α) exhibits immunological and metabolic activities involved in the induction and maintenance of immune responses. We attempted to evaluate the relationship between GD and serum TNF-α and its soluble receptors (sTNFRs), soluble TNF receptor 1 and 2 (sTNF-R1 and s TNF-R2). A total of 72 GD patients and 72 matched healthy individuals were recruited for this study. Serum TNF-α and sTNFRs were measured by sandwich ELISA. In our study, no s ignificant difference was observed in TNF-α, but sTNFRs were found to be significantly elevated in GD patients compared to healthy individuals. Serum sTNFR levels we re positively correlated with free triiodothyronine (FT3) and free thyroxine (FT4), and TNF-α was negatively correlated with thyroid-stimulating hormone (TSH) in the GD gro up. It was also shown that thyrotropin receptor antibody (TRAb) was positively correlated with TNF-α and sTNFRs. Spearman’s correlation analysis showed that only sTNF-R1 was po sitively correlated with complement C3. Multiple linear regression analysis suggests tha t serum levels of sTNF-R1 and FT4 may play an important role in the serum level of FT3. A ccording to the median value of FT3 level, GD patients were further divided into a hig h FT3 group and a low FT3 group. The serum levels of sTNF-R1 in the high FT3 GD group wer e significantly higher than those in the low FT3 GD group. In conclusion, sTNFRs may play a n important role in anti-inflammatory and immune response in GD.