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Lichen Planus is an inflammatory disorder of skin  and mucous    membrane, with approximately unknown etiology and pathogenesis. From    the clinical aspect, the disease is characterized by polygonal, purple, itchy    and plan papules. Pathological changes are various in dermis and    epidermis. One of those, is necrotic Keratinocyte or Civatte Body that seen    in lower layer of epidermis and specially in upper layer of dermis.           This investigation was a three years study of clinical and histopathological    characteristics of Lichen Planus and relationship between response of    Civatte body (Civ-b) and activity of the disease, in Sina hospital of    Hamadan city (1995-98). This study was an analytic cross sectional study,    and was performed by 106 files and microscopic slides of the patients    affected by Lichen Planus.           In this study, results showed that 75.8% of all dermis Civatte Body are in    active phase of disease and this number is 88.2% for epidermis. The    correlation between number of Civatte body and disease activity was    statistically established by Fisher’s exact test (P value < 0.001). On the other    hand, disease activity was also related to intensity of band from infiltration.    Also results confirm that the more Civatte Body in dermis, the more    epidermis Civatte Body.           In this research, it was established that the more Civatte body, the more    activity of Linchen planus and the decrease of Civatte Body shows    decrease activity and relieve of disease.