Therapeutic strategy for pandrug-resistant Klebsiella pneumoniae severe infections: short-course treatment with colistin increases the in vivo and in vitro activity of double carbapenem regimen
oleh: Alessandra Oliva, Maria T. Mascellino, Alessia Cipolla, Alessandra D’Abramo, Annalisa De Rosa, Stefano Savinelli, Maria Rosa Ciardi, Claudio M. Mastroianni, Vincenzo Vullo
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2015-04-01 |
Deskripsi
Infections due to carbapenemase-producing Klebsiella pneumoniae represent an emerging threat due to the high mortality rate and lack of valid antimicrobial combinations, especially when the strain is colistin-resistant. We report a case of bloodstream infection due to pandrug-resistant K. pneumoniae treated successfully with an innovative regimen comprising a combination of colistin plus double carbapenem, along with an in vitro analysis showing the synergistic and bactericidal effect.