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Objectives: To evaluate he effectiveness of postoperative medical treatment in the management of allergic fungal sinusitis with orbital and / or skull base erosin. Study Design: Descriptive study: Patients and Method: Eighteen cases of allergic fungal sinsusitis with orbital and / or skull base erosion were selected for the study. Demographic Data like, name, age, sex, address, clinical features, labs and imaging studies were recorded, clinical data including the pre and post-operative medical treament.