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Worsening of asthma is usually caused due to noncompliance to medications. The incidence of pulmonary arterial hypertension (PAH) due to asthma is very rare. There are many case reports where PAH was wrongly diagnosed as asthma. Pulmonary hypertension can be associated with asthma and makes a controlled asthma worsened. In our patient pulmonary embolism diagnosed by transesophageal echocardiography due to factor V leiden mutation was the responsible factor for pulmonary hypertension. After proper treatment of pulmonary embolism his asthma gets controlled again.