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Primary bone lymphoma is a rare disease. We report the rare case of relapsed indolent primary bone Lymphoma (PBL), which was effectively treated using Bendamustine and Rituximab. A male 78-years-old patient presented with a painful mass in the left arm associated to enlargement of lymph nodes in axillary region. The ultrasonography scan showed a patchy and hypoechoic area in the biceps that was 100x35mm, confirmed by CT scan. Indeed a whole body CT scan found pathological adenopathies in ipsilateral axillary region.The histological examination and immunohistochemical staining of the bone biopsy confirmed a diagnosis of B small cell  Lymphocytic Lymphoma, clinical stage IVA (according to the Ann Arbor Staging Classification for Lymphomas). Recommended treatments for PBL were used according to the guidelines , but relapses after an initial complete response occurred.  Once options recommended were exhausted, we decided to use a histology-driven approaches such as for the others NHL. According to Rummel experience, we decide to treat our patient with Bendamustin 90 mg/mq gg1-2 q28 plus Rituximab 375 mg/mq q28 (BR). Based on our experience, BR combination could be considered a good option for PBL relapsed with indolent subtype.