Anxiolytic-like effects of erythrinian alkaloids from erythrina suberosa
oleh: Maria Amélia Rodrigues Serrano, Andrea Nastri de Luca Batista, Vanderlan da Silva Bolzani, Luciana de Ávila Santos, Paulo José de Campos Nogueira, Ricardo Luiz Nunes-de-Souza, Abdul Latif, Mohammad Arfan
| Format: | Article |
|---|---|
| Diterbitkan: | Sociedade Brasileira de Química 2011-01-01 |
Deskripsi
Two alkaloids, erysodine (1) and erysothrine (2) were isolated from the flowers of a Pakistani medicinal plant, Erythrina suberosa. These compounds were investigated for anxiolytic properties, and the results showed significant effect, in an acute oral treatment with 1-2, which were suspended in saline (NaCl 0.9%) plus DMSO 1%, and evaluated in 122 Swiss male mice exposed to two tests of anxiety - the elevated plus-maze (EPM) and the light/dark transition model (LDTM).