3-Ethyl-2-(ethylimino)-4-methyl-2,3-dihydro-1,3-thiazole-5-carboxylate Ethyl Ester
oleh: Ge Meng, Mei Wang, Ya-Nan Cheng, Kai Chen, Jing Tong, Jie-He Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2016-11-01 |
Deskripsi
An efficient procedure to obtain the new compound 1a from ethyl acetoacetate (2a), NBS and N,N′-diethylthiourea (4a) was reported. In comparison with the traditional method to synthesize its analogues, this efficient, catalyst-free, and one-pot synthetic method is facile. The work-up procedure is easy and gives the pure target compound under milder reaction conditions in a relatively high yield of 75%.