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Tracking endocrine disease in mythology especially one as old and diverse as Indian mythology is a challenge. A curious case of sex reversal in the bhagavata purana is described and hunches about the disorder of sexual differentiation that manifested itself in the hapless Sudyumna the son of Manu is attempted. 5 alpha reductase deficiency appears to be the closest candidate but some twists in the tale are required to fill in the gaps.