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Objective: The purpose was to establish whether the advanced male age may influence the outcomes in a controlled assisted reproductive technology (ART) program. Design: This is an experimental study. Setting: Research and Clinical Center for Infertility of Yazd. Sample: A total of 63 men undergoing ART cycles. Material: In a retrospective study, the outcome of intracytoplasmic sperm injection (ICSI) in ART cycles in two groups of patients was studied. Patients regarding etiology of infertility were divided into two groups: (A) male factor infertility (n = 47), and (B) female factor infertility (n = 16). Sperm parameters, ART cycle characteristics and clinical outcomes were assessed between two groups. Main outcome measures: Clinical outcomes of ART in advanced aged men. Results: There were no significant differences in rates of sperm count and morphology between two groups, but the rate of spermatozoa with progressive motility were higher in group B in comparison with A (P = 0.002). The rates of high quality embryos, pregnancy and live birth showed no significant differences between the groups (P = 0.4, P = 0.4, P = 0.2, respectively). Conclusion: It appears that the clinical outcome of ART in male and female factor infertility was not influenced by advanced paternal age.