Protective host defense against disseminated candidiasis is impaired in mice expressing human interleukin-37
oleh: Frank L. Van De Veerdonk, Frank L. Van De Veerdonk, Frank L. Van De Veerdonk, Mark S Gresnigt, Jos WM Van Der Meer, Leo eJoosten, Leo eJoosten, Mihai eNetea, Mihai eNetea, Charles eDinarello, Charles eDinarello
| Format: | Article |
|---|---|
| Diterbitkan: | Frontiers Media S.A. 2015-01-01 |
Deskripsi
The effect of the anti-inflammatory cytokine interleukin-37 (IL 37) on host defense against Candida infections remains unknown. We assessed the role of IL 37 in a murine model of disseminated candidiasis using mice transgenic for human IL 37 (hIL 37Tg). Upon exposure to C. albicans pseudohyphae, macrophages from hIL-37Tg mice release 39% less TNFα compared to cells from wild-type mice (P=0.01). In vivo, hIL 37Tg mice displayed a decreased capacity to recruit neutrophils to the site of infection. These defects were associated with increased mortality and organ fungal growth in hIL-37Tg compared to wild-type mice. We conclude that IL-37 interferes with the innate protective anti-Candida host response by reducing the production of proinflammatory cytokines and suppressing neutrophil recruitment in response to Candida, resulting in an increased susceptibility to disseminated candidiasis.