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Aim. To study effects of stress, myorelaxation, and their combination on endothelium-dependent vasodilatation (EDVD) in healthy adolescents. Material and methods. In total, 19 healthy adolescents (8 boys, 11 girls) were examined; mean age 14,4±0,3 years. Central hemodynamics and brachial artery (BA) blood flow were assessed before and during reactive hyperemia test (RHT), with ultrasound system «ACUSON 128XP/10c» - at baseline, during counting aloud test, myorelaxation, or their combination. Results. During counting aloud test, a significant heart rate (HR) increase, with non-significant systolic and diastolic blood pressure (SBP, DBP) surge, was registered, without substantial dynamics of BA blood flow or EDVD parameters. In myorelaxation, significant decrease in HR and BP was associated with substantial increase of BA diameter during RHT-from 7,97±0,68% at baseline to 11,13±1,07% (p=0,0005). For combination of myorelaxation and counting aloud test, HR and BP figures were intermediate, EDVD remained high (11,52±1,23%), and BA blood flow was maximal. Conclusion. The data obtained support a possibility of using stress-limiting influences for improving endothelial stress-reactivity in preventive cardiology programs.