Structural analysis of the overoxidized Cu/Zn-superoxide dismutase in ROS-induced ALS filament formation
oleh: Yeongjin Baek, Tae-Gyun Woo, Jinsook Ahn, Dukwon Lee, Yonghoon Kwon, Bum-Joon Park, Nam-Chul Ha
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-10-01 |
Deskripsi
Characterization of the structure of an overoxidation-mimicking double mutant of superoxide dismutase SOD1 shows the production of more cytotoxic filaments seen in amyotrophic lateral sclerosis (ALS) neurons.