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Green chemistry nowadays is surpassing the idea of being a sheer lab inquisitiveness into the large-scale pharmaceutical application in industries. However, industries being one of the most dynamic area, always remain in the forefronts of any substantial changes. These changes in the terms of innovative ideas, conventional feed stocks, safer raw materials, and alternative mechanisms in laboratories at pilot scale seems fascinating to apply in industries. The purpose of this review is to present a selective overview of the green synthesis in the pharmaceutical industries where the green chemistry practices have been applied successfully. The green practices in the synthesis of drugs demonstrated in the review are some examples chosen based upon the optimal yield, solvent selection, biocatalysts and regioselectivity of some pharmaceutical products produced at large industrial scales. The objective is to overview the status of the integration of the green chemistry in the pharmaceutical industries and its problem and challenges with the emphasis of a way forward in this direction.