Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody
oleh: Tibor Füzik, Petra Formanová, Daniel Růžek, Kentaro Yoshii, Matthias Niedrig, Pavel Plevka
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-01-01 |
Deskripsi
The tick-borne encephalitis virus (TBEV) causes thousands of cases of meningitis and encephalitis annually. Here, the authors describe a cryo-EM structure of the TBEV virion bound by Fab fragments of the neutralizing antibody 19/1786, revealing a mechanism whereby this antibody prevents virus membrane fusion.