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Stage II testicular seminoma is defined by the presence of pure seminoma in the orchiectomy specimen and metastatic retroperitoneal lymph nodes. Chemotherapy or radiotherapy are recommended for low volume (size ≤ 5 cm) while chemotherapy is advised for patients with bulky disease (size > 5 cm). Chemotherapy is based on a combination of etoposide and cisplatin (4 cycles) or bleomycin, etoposide and cisplatin (3 cycles) whatever the size of retroperitoneal lymph nodes. We report two patients who achieved a 2-year sustained disease remission despite a reduced number of chemotherapy cycles because of septic complications or intercurrent viral infection. These observations suggest that new strategies are required to reduce the number of cycles and consequently long-term morbidity.