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With an increase in the use of high dose chemotherapeutic regimens, higher cure rates and longer survival periods of cancer patients, the incidence of secondary malignancies are increasing. Therapy related Myeloid Neoplasm (t-MN) is a second malignancy after chemotherapy/radiotherapy given for a prior malignancy. Of the various t-MN Acute Promyelocytic Leukaemia (APML) as a complication of chemo-radiotherapy is very rare. We report a rare case of therapy related APML in a breast cancer survivor.