Sc-compReg enables the comparison of gene regulatory networks between conditions using single-cell data
oleh: Zhana Duren, Wenhui Sophia Lu, Joseph G. Arthur, Preyas Shah, Jingxue Xin, Francesca Meschi, Miranda Lin Li, Corey M. Nemec, Yifeng Yin, Wing Hung Wong
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-08-01 |
Deskripsi
Changes in cell state underlie the difference between health and disease. Here, the authors propose a computational framework for the integration of gene expression and chromatin-accessibility data from single cells to identify differences in gene regulation in cell types across two conditions.