High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics
oleh: Thomas Mager, David Lopez de la Morena, Verena Senn, Johannes Schlotte, Anna D´Errico, Katrin Feldbauer, Christian Wrobel, Sangyong Jung, Kai Bodensiek, Vladan Rankovic, Lorcan Browne, Antoine Huet, Josephine Jüttner, Phillip G. Wood, Johannes J. Letzkus, Tobias Moser, Ernst Bamberg
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-05-01 |
Deskripsi
Optogenetic applications would benefit from channelrhodopsins (ChRs) with faster photostimulation, increased tissue transparency and lower phototoxicity. Here, the authors develop fast red-shifted ChR variants and show the abilities for temporal precise spiking of cerebral interneurons and restoring auditory activity in deaf mice.