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Objective- To determine the effect of selected bone graft on the compression properties of radial bone in rabbit. Design- Experimental in vivo study. Animals- A total of 45 adult male New Zealand white rabbits. Procedures- The rabbits were anesthetized and a one-cm-full thickness piece of radial bone was removed using oscillating saw in the all rabbit. The rabbits were divided into 5 groups on thebasis of the material used to fill the bone defect: group 1: the paste of bone cement calciumphosphate; group II: the paste of calcium phosphate mixture with type I collagen; group III:tricalcium phosphate mixed with hydroxyapatite (TCP & HP) with 5% porosity; group IV: thesame scaffold as group III with 10% porosity; and group V: the same scaffold as group III andIV with 20% porosity, with 9 rabbits in each group. Subsequently subdivided into 3 subgroupsof 3 rabbits each. Results- There was a significant increase in compression properties of radial bone in the group IIand V in 2nd and 3rd months as compared with groups I, III and IV. The mean endurable crackstrengthin group II and V were slightly higher than that of normal radius (P<0.05). Conclusion and Clinical Relevance- Application of calcium phosphate paste with type Icollagen and scaffold of tricalcium phosphate with hydroxyapatite having 20% porosityindicated to have positive effect in integral formation of qualitative callus at the site of fractureand early re-organization of callus to regain mechanical strength too.