A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis
oleh: Tsveta S. Malinova, Ana Angulo-Urarte, Julian Nüchel, Marina Tauber, Miesje M. van der Stoel, Vera Janssen, Annett de Haan, Anouk G. Groenen, Merel Tebbens, Mariona Graupera, Markus Plomann, Stephan Huveneers
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-05-01 |
Deskripsi
Communication between endothelial leader and follower cells during collective cell migration is crucial for vascular development. Here, the authors show that PACSIN2 guides collective cell migration and angiogenesis by recruiting a protein trafficking complex to asymmetric cell-cell junctions, controlling local junction plasticity.