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Iron overload and auto-oxidation of unpaired globin chains are  the main causes of oxidative stress in patients with thalassemia major. In the present study, we aimed to investigate the antioxidant effects of capparis ovatta and deferasirox in thalassemic patients. A total 40  patients with thalassemia major aged between 7-30 years, who have  been taken  regular red cell transfusion  and chelation (Deferasirox:30 mg/kg/day) for one  year are involved. They were divided into two groups as control and  study group randomly. Both study and control  groups were followed by  regular  transfusion and chelation therapy. In addition study group have been taken the marmalade of dried capparis ovata   the breakfast with a  daily dose of 12.5 gr younger than 10 years and 25 gr older than 10 years for 6 months. Hematological, biochemical parameters, ferritin at every month and antioxidant enzymes (MDA, CAT, GPX, SOD) were measured at the beginning and at the end of the study.  There was  a significant difference between initial and final parameters  of the MDA levels in study group. SOD levels  also decreased statistically in both of the groups, CAT  and GPX levels didn’t decrease significantly  in both of the groups. Ferritin levels declined significiantly both in control and study group. As conclusion,  our findings suggest that combination of  capparis  ovata with deferasirox  may   have additive effect on decreasing the oxidative damage and hepatoxicity.  This is preliminary work, it needs further works.